The Padres (79-83) were defeated by the San Francisco Giants by a score of 11-4 in the finale of their three-game series at Oracle Park and the final game of the 2021 season. Reiss Knehr (1-2, 4.97) allowed two runs on three hits and two walks with two strikeouts in three innings. Buster Posey‘s third inning bases-loaded single drove in Logan Webb & Wilmer Flores. Tommy La Stella singled to score Kris Bryant, Flores doubled to drive in Mike Yastrzemski & Webb, La Stella scored on a LaMonte Wade Jr. sacrifice fly, and Posey drove in Flores with a single in the fourth inning. Webb hit a two-run home run in the fifth inning. Yastrzemski doubled to drive in Brandon Crawford & Bryant in the seventh inning.
Webb (11-3, 3.03) gave up four runs on six hits and no walks while striking out eight over seven innings. Manny Machado‘s fourth inning sacrifice fly drove in Trent Grisham. Victor Caratini singled to drive in Jake Marisnick, Grisham singled to score Webster Rivas, and Caratini scored on a Jake Cronenworth sacrifice fly in the eighth inning.